The StreamFlow framework is a container-native Workflow Management System (WMS) written in Python 3 and based on the Common Workflow Language (CWL) open standard. It has been designed around two main principles: allow the execution of tasks in multi-container environments, in order to support concurrent execution of multiple communicating tasks in a multi-agent ecosystem, and relax the requirement of a single shared data space, in order to allow for hybrid workflow executions on top of multi-cloud or hybrid cloud/HPC infrastructures.